Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells

Activation of the epidermal growth factor (EGF) receptor (EGFR) at the cell surface initiates signaling through the RAS-RAF-MAPK/ERK1/2 pathway and receptor endocytosis. Whether this signaling continues from endosomes remains unclear, because RAS is predominantly located on the plasma membrane, and...

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Publicat a:Mol Biol Cell
Autors principals: Surve, Sachin V., Myers, Paul J., Clayton, Samantha A., Watkins, Simon C., Lazzara, Matthew J., Sorkin, Alexander
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2019
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594441/
https://ncbi.nlm.nih.gov/pubmed/30586319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-08-0512
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