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EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We labeled endogenous EGFR with GFP by genome-editing of human oral squamous cell carcinoma cells, which were used to examine EGF...

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Bibliographic Details
Published in:eLife
Main Authors: Pinilla-Macua, Itziar, Grassart, Alexandre, Duvvuri, Umamaheswar, Watkins, Simon C, Sorkin, Alexander
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741375/
https://ncbi.nlm.nih.gov/pubmed/29268862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31993
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