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EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We labeled endogenous EGFR with GFP by genome-editing of human oral squamous cell carcinoma cells, which were used to examine EGF...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pinilla-Macua, Itziar, Grassart, Alexandre, Duvvuri, Umamaheswar, Watkins, Simon C, Sorkin, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741375/
https://ncbi.nlm.nih.gov/pubmed/29268862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31993
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