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Endocytosis of ubiquitylation-deficient EGF receptor mutants via clathrin coated pits is mediated by ubiquitylation
Signaling by EGF receptor (EGFR) is controlled by endocytosis. However, mechanisms of EGFR endocytosis remain poorly understood. Here we found that the EGFR mutant lacking known ubiquitylation, acetylation and clathrin adaptor AP-2 binding sites (21KRΔAP2) was internalized at relatively high rates v...
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| Izdano u: | Traffic |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607634/ https://ncbi.nlm.nih.gov/pubmed/26251007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12314 |
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