Endocytosis of ubiquitylation-deficient EGF receptor mutants via clathrin coated pits is mediated by ubiquitylation

Signaling by EGF receptor (EGFR) is controlled by endocytosis. However, mechanisms of EGFR endocytosis remain poorly understood. Here we found that the EGFR mutant lacking known ubiquitylation, acetylation and clathrin adaptor AP-2 binding sites (21KRΔAP2) was internalized at relatively high rates v...

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Veröffentlicht in:Traffic
Hauptverfasser: Fortian, Arola, Dionne, Lai Kuan, Hong, Sun Hae, Kim, Woong, Gygi, Steven P., Watkins, Simon, Sorkin, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607634/
https://ncbi.nlm.nih.gov/pubmed/26251007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12314
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