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EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We labeled endogenous EGFR with GFP by genome-editing of human oral squamous cell carcinoma cells, which were used to examine EGF...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Pinilla-Macua, Itziar, Grassart, Alexandre, Duvvuri, Umamaheswar, Watkins, Simon C, Sorkin, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741375/
https://ncbi.nlm.nih.gov/pubmed/29268862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31993
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