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Quantitative Analysis of Endocytosis and Turnover of Epidermal Growth Factor (EGF) and EGF Receptor

Binding of epidermal growth factor (EGF) to the EGF receptor (EGFR) initiates signal transduction, ultimately leading to altered gene expression. Ligand-activated EGFR is also rapidly internalized and then targeted to lysosomes for degradation or recycled back to the plasma membrane. Endocytosis is...

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Autors principals: Sorkin, Alexander, Duex, Jason E.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878126/
https://ncbi.nlm.nih.gov/pubmed/20235100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471143030.cb1514s46
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