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Growth Factor Receptor Binding Protein 2-mediated Recruitment of the RING Domain of Cbl to the Epidermal Growth Factor Receptor Is Essential and Sufficient to Support Receptor Endocytosis

Knockdown of growth factor receptor binding protein 2 (Grb2) by RNA interference strongly inhibits clathrin-mediated endocytosis of the epidermal growth factor receptor (EGFR). To gain insights into the function of Grb2 in EGFR endocytosis, we have generated cell lines in which endogenous Grb2 was r...

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Bibliografiske detaljer
Main Authors: Huang, Fangtian, Sorkin, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC551491/
https://ncbi.nlm.nih.gov/pubmed/15635092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-09-0832
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