IMPAIRED SHP2-MEDIATED ERK ACTIVATION CONTRIBUTES TO GEFITINIB SENSITIVITY OF LUNG CANCER CELLS WITH EGFR-ACTIVATING MUTATIONS

Most non-small cell lung cancers (NSCLC) display elevated expression of epidermal growth factor receptor (EGFR), but response to EGFR kinase inhibitors is predominantly limited to NSCLC harboring EGFR-activating mutations. These mutations are associated with increased activity of survival pathways i...

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Detalhes bibliográficos
Main Authors: Lazzara, Matthew J., Lane, Keara, Chan, Richard, Jasper, Paul J., Yaffe, Michael B., Sorger, Peter K., Jacks, Tyler, Neel, Benjamin G., Lauffenburger, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862125/
https://ncbi.nlm.nih.gov/pubmed/20406974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3421
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