ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers

Suicide gene therapies provide a unique ability to target cancer cells selectively, often based on modification of viral tropism or transcriptional regulation of therapeutic gene expression. We designed a novel suicide gene therapy approach wherein the gene product (herpes simplex virus thymidine ki...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Day, Evan K., Campbell, Anne, Pandolf, Ashley, Rogerson, Troy, Zhong, Qing, Xiao, Aizhen, Purow, Benjamin, Lazzara, Matthew J.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058433/
https://ncbi.nlm.nih.gov/pubmed/33333291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.019
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