Identification of existing drugs that effectively target NTRK1- and ROS1-rearrangements in lung cancer

PURPOSE: Efforts to discover drugs that overcome resistance to targeted therapies in patients with rare oncogenic alterations, such as NTRK1- and ROS1-rearrangements, are complicated by the cost and protracted timeline of drug discovery. EXPERIMENTAL DESIGN: In an effort to identify inhibitors of NT...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Chong, Curtis R., Bahcall, Magda, Capelletti, Marzia, Kosaka, Takayuki, Ercan, Dalia, Sim, Taebo, Sholl, Lynette M., Nishino, Mizuki, Johnson, Bruce E., Gray, Nathanael S., Jänne, Pasi A.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203969/
https://ncbi.nlm.nih.gov/pubmed/27370605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1601
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