Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transi...

Por Milian, Lara, Mata, Manuel, Alcacer, Javier, Oliver, María, Sancho-Tello, María, Martín de Llano, José Javier, Camps, Carlos, Galbis, José, Carretero, Julian, Carda, Carmen
Publicado no PLoS One (2020)

Loss of p53 Attenuates the Contribution of IL-6 Deletion on Suppressed Tumor Progression and Extended Survival in Kras-Driven Murine Lung Cancer

Por Tan, Xiaohong, Carretero, Julian, Chen, Zhao, Zhang, Jishuai, Wang, Yanxiao, Chen, Jicheng, Li, Xiubin, Ye, Hui, Tang, Chuanhao, Cheng, Xuan, Hou, Ning, Yang, Xiao, Wong, Kwok-Kin
Publicado em 2013

β-catenin contributes to lung tumor development induced by EGFR mutations

Por Nakayama, Sohei, Sng, Natasha, Carretero, Julian, Welner, Robert, Hayashi, Yuichiro, Yamamoto, Mihoko, Tan, Alistair J., Yamaguchi, Norihiro, Yasuda, Hiroyuki, Li, Danan, Soejima, Kenzo, Soo, Ross A., Costa, Daniel B., Wong, Kwok-Kin, Kobayashi, Susumu S.
Publicado em 2014

PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Por Bonastre, Ester, Verdura, Sara, Zondervan, Ilse, Facchinetti, Federica, Lantuejoul, Sylvie, Chiara, Maria Dolores, Rodrigo, Juan Pablo, Carretero, Julian, Condom, Enric, Vidal, Agustin, Sidransky, David, Villanueva, Alberto, Roz, Luca, Brambilla, Elisabeth, Savola, Suvi, Sanchez-Cespedes, Montse
Publicado no Cancer Res (2015)

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

Por Shimamura, Takeshi, Chen, Zhao, Soucheray, Margaret, Carretero, Julian, Kikuchi, Eiki, Tchaicha, Jeremy H., Gao, Yandi, Cheng, Katherine A., Cohoon, Travis J., Qi, Jun, Akbay, Esra, Kimmelman, Alec C., Kung, Andrew L., Bradner, James E., Wong, Kwok-Kin
Publicado em 2013

Intratumoral heterogeneity in EGFR mutant NSCLC results in divergent resistance mechanisms in response to EGFR tyrosine kinase inhibition

Por Soucheray, Margaret, Capelletti, Marzia, Pulido, Inés, Kuang, Yanan, Paweletz, Cloud P., Becker, Jeffrey H., Kikuchi, Eiki, Xu, Chunxiao, Patel, Tarun B., Al-shahrour, Fatima, Carretero, Julián, Wong, Kwok-Kin, Jänne, Pasi A., Shapiro, Geoffrey I., Shimamura, Takeshi
Publicado no Cancer Res (2015)

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data

Por Piñeiro-Yáñez, Elena, Reboiro-Jato, Miguel, Gómez-López, Gonzalo, Perales-Patón, Javier, Troulé, Kevin, Rodríguez, José Manuel, Tejero, Héctor, Shimamura, Takeshi, López-Casas, Pedro Pablo, Carretero, Julián, Valencia, Alfonso, Hidalgo, Manuel, Glez-Peña, Daniel, Al-Shahrour, Fátima
Publicado no Genome Med (2018)

Expression inactivation of SMARCA4 by microRNAs in lung tumors

Por Coira, Isabel F., Rufino-Palomares, Eva E., Romero, Octavio A., Peinado, Paola, Metheetrairut, Chanatip, Boyero-Corral, Laura, Carretero, Julian, Farez-Vidal, Esther, Cuadros, Marta, Reyes-Zurita, Fernando J., Lupiáñez, Jose A., Sánchez-Cespedes, Montse, Slack, Frank J., Medina, Pedro P.
Publicado no Hum Mol Genet (2015)

Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response

Por Weaver, Zoë, Difilippantonio, Simone, Carretero, Julian, Martin, Philip L., El Meskini, Rajaa, Iacovelli, Anthony J., Gumprecht, Michelle, Kulaga, Alan, Guerin, Theresa, Schlomer, Jerome, Baran, Maureen, Kozlov, Serguei, McCann, Thomas, Mena, Salvador, Al-Shahrour, Fatima, Alexander, Danny, Wong, Kwok-Kin, Van Dyke, Terry
Publicado em 2012

Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer

Por Shimamura, Takeshi, Perera, Samanthi A., Foley, Kevin P., Sang, Jim, Rodig, Scott J., Inoue, Takayo, Chen, Liang, Li, Danan, Carretero, Julian, Li, Yu-Chen, Sinha, Papiya, Carey, Christopher D., Borgman, Christa L., Jimenez, John-Paul, Meyerson, Matthew, Ying, Weiwen, Barsoum, James, Wong, Kwok-Kin, Shapiro, Geoffrey I.
Publicado em 2012

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer

Por Singh, Anju, Ruiz, Christian, Bhalla, Kavita, Haley, John A., Li, Qing Kay, Acquaah-Mensah, George, Montal, Emily, Sudini, Kuladeep R., Skoulidis, Ferdinandos, Wistuba, Ignacio I., Papadimitrakopoulou, Vassiliki, Heymach, John V., Boros, Laszlo G., Gabrielson, Edward, Carretero, Julian, Wong, Kwok-Kin, Haley, John D., Biswal, Shyam, Girnun, Geoffrey D.
Publicado no FASEB J (2018)

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Por Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., Jackson, Autumn L., Nikolinakos, Petros, Ospina, Beatriz, Naumov, George, Brandstetter, Kathleyn A., Weigman, Victor J., Zaghlul, Sara, Hayes, D. Neil, Padera, Robert F., Heymach, John V., Kung, Andrew L., Sharpless, Norman E., Kaelin, William G., Wong, Kwok-Kin
Publicado em 2009

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Por Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., Jackson, Autumn L., Nikolinakos, Petros, Ospina, Beatriz, Naumov, George N., Brandstetter, Kathleyn A., Weigman, Victor J., Zaghlul, Sara, Hayes, D. Neil, Padera, Robert F., Heymach, John V., Kung, Andrew L., Sharpless, Norman E., Kaelin, William G., Wong, Kwok-Kin
Publicado em 2009

Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Por Chen, Zhao, Sasaki, Takaaki, Tan, Xiaohong, Carretero, Julian, Shimamura, Takeshi, Li, Danan, Xu, Chunxiao, Wang, Yuchuan, Adelmant, Guillaume O., Capelletti, Marzia, Lee, Hyun Joo, Rodig, Scott J., Borgman, Christa, Park, Seung-il, Kim, Hyeong Ryul, Padera, Robert, Marto, Jarrod A., Gray, Nathanael S., Kung, Andrew L., Shapiro, Geoffrey I., Jänne, Pasi A., Wong, Kwok-Kin
Publicado em 2010

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

Por Straume, Oddbjørn, Shimamura, Takeshi, Lampa, Michael J. G., Carretero, Julian, Øyan, Anne M., Jia, Di, Borgman, Christa L., Soucheray, Margaret, Downing, Sean R., Short, Sarah M., Kang, Soo-Young, Wang, Souming, Chen, Liang, Collett, Karin, Bachmann, Ingeborg, Wong, Kwok-Kin, Shapiro, Geoffrey I., Kalland, Karl Henning, Folkman, Judah, Watnick, Randolph S., Akslen, Lars A., Naumov, George N.
Publicado em 2012

Interleukin-17A Promotes Lung Tumor Progression Through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade

Por Akbay, Esra A., Koyama, Shohei, Liu, Yan, Dries, Ruben, Bufe, Lauren E., Silkes, Michael, Alam, Maksudul, Magee, Dillon M., Jones, Robert, Jinushi, Masahisa, Kulkarni, Meghana, Carretero, Julian, Wang, Xiaoen, Warner-Hatten, Tiquella, Cavanaugh, Jillian D., Bufe, Lauren E., Osa, Akio, Kumanogoh, Atsushi, Freeman, Gordon J., Awad, Mark M, Christiani, David C., Bueno, Raphael, Hammerman, Peter S., Dranoff, Glenn, Wong, Kwok-Kin
Publicado no J Thorac Oncol (2017)

Targeting Transcriptional Addictions In Small Cell Lung Cancer With a Covalent CDK7 Inhibitor

Por Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian, Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin
Publicado no Cancer Cell (2014)

Integrative genomic and proteomic analyses identify targets for Lkb1 deficient metastatic lung tumors

Por Carretero, Julian, Shimamura, Takeshi, Rikova, Klarisa, Jackson, Autumn L., Wilkerson, Matthew D., Borgman, Christa L., Buttarazzi, Matthew S., Sanofsky, Benjamin A., McNamara, Kate L., Brandstetter, Kathleyn A., Walton, Zandra E., Gu, Ting-Lei, Silva, Jeffrey C., Crosby, Katherine, Shapiro, Geoffrey I., Maira, Michel, Ji, Hongbin, Castrillon, Diego H., Kim, Carla F, García-Echeverría, Carlos, Bardeesy, Nabeel, Sharpless, Norman E., Hayes, Neil D., Kim, William Y., Engelman, Jeffrey A., Wong, Kwok-Kin
Publicado em 2010

CXCR7 reactivates ERK signaling to promote resistance to EGFR kinase inhibitors in NSCLC.

Por Becker, Jeffrey H., Gao, Yandi, Soucheray, Margaret, Pulido, Ines, Kikuchi, Eiki, Rodríguez, María L., Gandhi, Rutu, Lafuente-Sanchis, Aranzazu, Aupí, Miguel, Fernández-Coronado, Javier Alcácer, Martín-Martorell, Paloma, Cremades, Antonio, Galbis-Caravajal, José M., Alcácer, Javier, Christensen, Camilla L., Simms, Patricia, Hess, Ashley, Asahina, Hajime, Kahle, Michael P., Al-Shahrour, Fatima, Borgia, Jeffrey A., Lahoz, Agustín, Insa, Amelia, Juan, Oscar, Jänne, Pasi A., Wong, Kwok-Kin, Carretero, Julian, Shimamura, Takeshi
Publicado no Cancer Res (2019)

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

Por Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D. Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin
Publicado em 2013