Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

PURPOSE: Amplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion and drug resistance. Murine genetics has established both the centrality of somatic alterations of Kras in lung cancer, as well as the d...

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Detalhes bibliográficos
Main Authors: Shimamura, Takeshi, Chen, Zhao, Soucheray, Margaret, Carretero, Julian, Kikuchi, Eiki, Tchaicha, Jeremy H., Gao, Yandi, Cheng, Katherine A., Cohoon, Travis J., Qi, Jun, Akbay, Esra, Kimmelman, Alec C., Kung, Andrew L., Bradner, James E., Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838895/
https://ncbi.nlm.nih.gov/pubmed/24045185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3904
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