Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have been lacking. We conducted a cell-based screen of genetically-defined cancer cell lines using a prototypica...

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Bibliografiske detaljer
Main Authors: Puissant, Alexandre, Frumm, Stacey M., Alexe, Gabriela, Bassil, Christopher F., Qi, Jun, Chanthery, Yvan H., Nekritz, Erin A., Zeid, Rhamy, Gustafson, W. Clay, Greninger, Patricia, Garnett, Matthew J., McDermott, Ultan, Benes, Cyril H., Kung, Andrew L., Weiss, William A., Bradner, James E., Stegmaier, Kimberly
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672953/
https://ncbi.nlm.nih.gov/pubmed/23430699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0418
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