Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have been lacking. We conducted a cell-based screen of genetically-defined cancer cell lines using a prototypica...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Puissant, Alexandre, Frumm, Stacey M., Alexe, Gabriela, Bassil, Christopher F., Qi, Jun, Chanthery, Yvan H., Nekritz, Erin A., Zeid, Rhamy, Gustafson, W. Clay, Greninger, Patricia, Garnett, Matthew J., McDermott, Ultan, Benes, Cyril H., Kung, Andrew L., Weiss, William A., Bradner, James E., Stegmaier, Kimberly
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672953/
https://ncbi.nlm.nih.gov/pubmed/23430699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0418
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi