Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

The MYCN proto-oncogene is associated with poor outcome across a broad range of pediatric tumors. While amplification of MYCN drives subsets of high-risk neuroblastoma and medulloblastoma, dysregulation of MYCN in medulloblastoma (in the absence of amplification) also contributes to pathogenesis. Si...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Cage, Tene Aneka, Chanthery, Yvan, Chesler, Louis, Grimmer, Matthew, Knight, Zachary, Shokat, Kevan, Weiss, William A., Gustafson, W. Clay
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429235/
https://ncbi.nlm.nih.gov/pubmed/26029667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00111
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