Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

MYC oncoproteins deliver a potent oncogenic stimulus in several human cancers, making them major targets for drug development, but efforts to deliver clinically practical therapeutics have not yet been realized. In childhood cancer, aberrant expression of MYC and MYCN genes delineates a group of agg...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vaughan, Lynsey, Clarke, Paul A., Barker, Karen, Chanthery, Yvan, Gustafson, Clay W., Tucker, Elizabeth, Renshaw, Jane, Raynaud, Florence, Li, Xiaodun, Burke, Rosemary, Jamin, Yann, Robinson, Simon P., Pearson, Andrew, Maira, Michel, Weiss, William A., Workman, Paul, Chesler, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295370/
https://ncbi.nlm.nih.gov/pubmed/27438153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10544
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