The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo

The Aurora kinases regulate key stages of mitosis including centrosome maturation, spindle assembly, chromosome segregation and cytokinesis. Aurora A and B overexpression has also been associated with various human cancers and as such, they have been extensively studied as novel anti-mitotic drug ta...

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Publicado no:Mol Cancer Ther
Main Authors: Faisal, Amir, Vaughan, Lynsey, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Avery, Sian, Jamin, Yann, Robinson, Simon P., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Chesler, Louis, Linardopoulos, Spiros
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298164/
https://ncbi.nlm.nih.gov/pubmed/21885865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0333
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