Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

[Image: see text] Aurora-A differs from Aurora-B/C at three positions in the ATP-binding pocket (L215, T217, and R220). Exploiting these differences, crystal structures of ligand–Aurora protein interactions formed the basis of a design principle for imidazo[4,5-b]pyridine-derived Aurora-A-selective...

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Bibliografische gegevens
Hoofdauteurs: Bavetsias, Vassilios, Faisal, Amir, Crumpler, Simon, Brown, Nathan, Kosmopoulou, Magda, Joshi, Amar, Atrash, Butrus, Pérez-Fuertes, Yolanda, Schmitt, Jessica A., Boxall, Katherine J., Burke, Rosemary, Sun, Chongbo, Avery, Sian, Bush, Katherine, Henley, Alan, Raynaud, Florence I., Workman, Paul, Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2013
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848336/
https://ncbi.nlm.nih.gov/pubmed/24195668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401115g
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