7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

Introduction of a 1-benzyl-1H-pyrazol-4-yl moiety at C7 of the imidazo[4,5-b]pyridine scaffold provided 7a which inhibited a range of kinases including Aurora-A. Modification of the benzyl group in 7a, and subsequent co-crystallisation of the resulting analogues with Aurora-A indicated distinct diff...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Bavetsias, Vassilios, Pérez-Fuertes, Yolanda, McIntyre, Patrick J., Atrash, Butrus, Kosmopoulou, Magda, O’Fee, Lisa, Burke, Rosemary, Sun, Chongbo, Faisal, Amir, Bush, Katherine, Avery, Sian, Henley, Alan, Raynaud, Florence I., Linardopoulos, Spiros, Bayliss, Richard, Blagg, Julian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science Ltd 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577729/
https://ncbi.nlm.nih.gov/pubmed/26296477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.003
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