HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non–small cell lung cancer (NSCLC), high HIF2α levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene V...

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Hauptverfasser: Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., Jackson, Autumn L., Nikolinakos, Petros, Ospina, Beatriz, Naumov, George, Brandstetter, Kathleyn A., Weigman, Victor J., Zaghlul, Sara, Hayes, D. Neil, Padera, Robert F., Heymach, John V., Kung, Andrew L., Sharpless, Norman E., Kaelin, William G., Wong, Kwok-Kin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719950/
https://ncbi.nlm.nih.gov/pubmed/19662677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38443
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