HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non–small cell lung cancer (NSCLC), high HIF2α levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene V...

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Main Authors: Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., Jackson, Autumn L., Nikolinakos, Petros, Ospina, Beatriz, Naumov, George, Brandstetter, Kathleyn A., Weigman, Victor J., Zaghlul, Sara, Hayes, D. Neil, Padera, Robert F., Heymach, John V., Kung, Andrew L., Sharpless, Norman E., Kaelin, William G., Wong, Kwok-Kin
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719950/
https://ncbi.nlm.nih.gov/pubmed/19662677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38443
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