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Loss of fibroblast HIF-1α accelerates tumorigenesis

Solid tumors consist of malignant cells and associated stromal components, including fibroblastic cells that contribute to tumor growth and progression. Although tumor fibrosis and aberrant vascularization contribute to the hypoxia often found in advanced tumors, the contribution of hypoxic signalin...

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Detalhes bibliográficos
Main Authors: Kim, Jung-whan, Evans, Colin, Weidemann, Alexander, Takeda, Norihiko, Lee, Yun Sok, Stockmann, Christian, Branco-Price, Cristina, Brandberg, Filip, Leone, Gustavo, Ostrowski, Michael C., Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089958/
https://ncbi.nlm.nih.gov/pubmed/22556263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0534
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