Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

Hypoxic response and inflammation both involve the action of the hypoxia-inducible transcription factors HIF-1α and HIF-2α. Previous studies have revealed that both HIF-α proteins are in a number of aspects similarly regulated post-translationally. However, the functional interrelationship of these...

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Detalhes bibliográficos
Main Authors: Takeda, Norihiko, O'Dea, Ellen L., Doedens, Andrew, Kim, Jung-whan, Weidemann, Alexander, Stockmann, Christian, Asagiri, Masataka, Simon, M. Celeste, Hoffmann, Alexander, Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827844/
https://ncbi.nlm.nih.gov/pubmed/20194441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1881410
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