HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non–small cell lung cancer (NSCLC), high HIF2α levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene V...

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Hlavní autoři: Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., Jackson, Autumn L., Nikolinakos, Petros, Ospina, Beatriz, Naumov, George, Brandstetter, Kathleyn A., Weigman, Victor J., Zaghlul, Sara, Hayes, D. Neil, Padera, Robert F., Heymach, John V., Kung, Andrew L., Sharpless, Norman E., Kaelin, William G., Wong, Kwok-Kin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719950/
https://ncbi.nlm.nih.gov/pubmed/19662677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38443
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