Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer

PURPOSE: We describe the anticancer activity of ganetespib, a novel non-geldanamycin heat shock protein 90 (HSP90) inhibitor, in non-small cell lung cancer (NSCLC) models. EXPERIMENTAL DESIGN: The activity of ganetespib was compared to that of the geldanamycin 17-AAG in biochemical assays, cell line...

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Detalhes bibliográficos
Main Authors: Shimamura, Takeshi, Perera, Samanthi A., Foley, Kevin P., Sang, Jim, Rodig, Scott J., Inoue, Takayo, Chen, Liang, Li, Danan, Carretero, Julian, Li, Yu-Chen, Sinha, Papiya, Carey, Christopher D., Borgman, Christa L., Jimenez, John-Paul, Meyerson, Matthew, Ying, Weiwen, Barsoum, James, Wong, Kwok-Kin, Shapiro, Geoffrey I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477583/
https://ncbi.nlm.nih.gov/pubmed/22806877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2967
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