Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinases are established Hsp90 client proteins and here w...

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Bibliografski detalji
Glavni autori: Proia, David A., Foley, Kevin P., Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C., Liu, Yuan, Rosenberg, Alex F., Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077378/
https://ncbi.nlm.nih.gov/pubmed/21533169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018552
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