Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer

BACKGROUND: The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose of the following study was to extend th...

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Main Authors: London, Cheryl A., Bear, Misty D., McCleese, Jennifer, Foley, Kevin P., Paalangara, Reji, Inoue, Takayo, Ying, Weiwen, Barsoum, James
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207826/
https://ncbi.nlm.nih.gov/pubmed/22073242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027018
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