De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer

Oncogenic Kras mutations are one of the most common alterations in non-small cell lung cancer and are associated with poor response to treatment and reduced survival. Driver oncogenes, such as Kras are now appreciated for their ability to promote tumor growth via up-regulation of anabolic pathways....

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Singh, Anju, Ruiz, Christian, Bhalla, Kavita, Haley, John A., Li, Qing Kay, Acquaah-Mensah, George, Montal, Emily, Sudini, Kuladeep R., Skoulidis, Ferdinandos, Wistuba, Ignacio I., Papadimitrakopoulou, Vassiliki, Heymach, John V., Boros, Laszlo G., Gabrielson, Edward, Carretero, Julian, Wong, Kwok-Kin, Haley, John D., Biswal, Shyam, Girnun, Geoffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219836/
https://ncbi.nlm.nih.gov/pubmed/29906244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800204
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