Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer

BACKGROUND: Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements, cancer cells will utilize alternative fuel s...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Montal, Emily D., Bhalla, Kavita, Dewi, Ruby E., Ruiz, Christian F., Haley, John A., Ropell, Ashley E., Gordon, Chris, Haley, John D., Girnun, Geoffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670241/
https://ncbi.nlm.nih.gov/pubmed/31388420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0199-6
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