Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhang, Haikuo, Fillmore Brainson, Christine, Koyama, Shohei, Redig, Amanda J., Chen, Ting, Li, Shuai, Gupta, Manav, Garcia-de-Alba, Carolina, Paschini, Margherita, Herter-Sprie, Grit S., Lu, Gang, Zhang, Xin, Marsh, Bryan P., Tuminello, Stephanie J., Xu, Chunxiao, Chen, Zhao, Wang, Xiaoen, Akbay, Esra A., Zheng, Mei, Palakurthi, Sangeetha, Sholl, Lynette M., Rustgi, Anil K., Kwiatkowski, David J., Diehl, J Alan, Bass, Adam J., Sharpless, Norman E., Dranoff, Glenn, Hammerman, Peter S., Ji, Hongbin, Bardeesy, Nabeel, Saur, Dieter, Watanabe, Hideo, Kim, Carla F., Wong, Kwok-Kin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385585/
https://ncbi.nlm.nih.gov/pubmed/28387316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14922
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