STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T cell activity in the lung tumor microenvironment

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether inactivation of tumor suppressor...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Aref, Amir R., Skoulidis, Ferdinandos, Herter-Sprie, Grit S., Buczkowski, Kevin A., Liu, Yan, Awad, Mark M., Denning, Warren L., Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R., Wistuba, Ignacio I., Soucheray, Margaret, Thai, Tran C., Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D., Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E., Shimamura, Takeshi, Hellmann, Matthew D., Heymach, John V., Hodi, F. Stephen, Freeman, Gordon J., Barbie, David A., Dranoff, Glenn, Hammerman, Peter S., Wong, Kwok-Kin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775354/
https://ncbi.nlm.nih.gov/pubmed/26833127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1439
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