STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma

KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade...

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Yayımlandı:Cancer Discov
Asıl Yazarlar: Skoulidis, Ferdinandos, Goldberg, Michael E., Greenawalt, Danielle M., Hellmann, Matthew D., Awad, Mark M., Gainor, Justin F., Schrock, Alexa B., Hartmaier, Ryan J., Trabucco, Sally E., Gay, Laurie, Ali, Siraj M., Elvin, Julia A., Singal, Gaurav, Ross, Jeffrey S., Fabrizio, David, Szabo, Peter M., Chang, Han, Sasson, Ariella, Srinivasan, Sujaya, Kirov, Stefan, Szustakowski, Joseph, Vitazka, Patrik, Edwards, Robin, Bufill, Jose A., Sharma, Neelesh, Ou, Sai-Hong I., Peled, Nir, Spigel, David R., Rizvi, Hira, Aguilar, Elizabeth Jimenez, Carter, Brett W., Erasmus, Jeremy, Halpenny, Darragh F., Plodkowski, Andrew J., Long, Niamh M., Nishino, Mizuki, Denning, Warren L., Galan-Cobo, Ana, Hamdi, Haifa, Hirz, Taghreed, Tong, Pan, Wang, Jing, Rodriguez-Canales, Jaime, Villalobos, Pamela A., Parra, Edwin R., Kalhor, Neda, Sholl, Lynette M., Sauter, Jennifer L., Jungbluth, Achim A., Mino-Kenudson, Mari, Azimi, Roxana, Elamin, Yasir Y., Zhang, Jianjun, Leonardi, Giulia C., Jiang, Fei, Wong, Kwok-Kin, Lee, J. Jack, Papadimitrakopoulou, Vassiliki A., Wistuba, Ignacio I., Miller, Vincent A., Frampton, Garrett M., Wolchok, Jedd D., Shaw, Alice T., Jänne, Pasi A., Stephens, Philip J., Rudin, Charles M., Geese, William J., Albacker, Lee A., Heymach, John V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030433/
https://ncbi.nlm.nih.gov/pubmed/29773717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0099
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