Approach to evaluating tumor mutational burden in routine clinical practice

Por Truesdell, John, Miller, Vincent A., Fabrizio, David
Publicado no Transl Lung Cancer Res (2018)

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies

Por Hartmaier, Ryan J., Charo, Jehad, Fabrizio, David, Goldberg, Michael E., Albacker, Lee A., Pao, William, Chmielecki, Juliann
Publicado no Genome Med (2017)

EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION

Por Campbell, Brittany B, Morgenstern, Daniel A, Lipman, Tatiana, Fabrizio, David, Shlien, Adam, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Publicado no Neuro Oncol (2018)

A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin

Por Wensel, David, Sun, Yongnian, Davis, Jonathan, Li, Zhufang, Zhang, Sharon, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark
Publicado no J Virol (2018)

Evidence‐Based Development and Clinical Use of Precision Oncology Therapeutics

Por Comment, Leah A., Ward, Ashley F., Schrock, Alexa B., Fabrizio, David, Venstrom, Jeffrey M., Hegde, Priti S., Alexander, Brian M.
Publicado no Clin Pharmacol Ther (2020)

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity

Por Wensel, David, Sun, Yongnian, Li, Zhufang, Zhang, Sharon, Picarillo, Caryn, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark, Davis, Jonathan
Publicado no Antimicrob Agents Chemother (2017)

Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence

Por Klempner, Samuel J., Fabrizio, David, Bane, Shalmali, Reinhart, Marcia, Peoples, Tim, Ali, Siraj M., Sokol, Ethan S., Frampton, Garrett, Schrock, Alexa B., Anhorn, Rachel, Reddy, Prasanth
Publicado no Oncologist (2019)

Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma

Por Ang, Celina, Klempner, Samuel J., Ali, Siraj M., Madison, Russell, Ross, Jeffrey S., Severson, Eric A., Fabrizio, David, Goodman, Aaron, Kurzrock, Razelle, Suh, James, Millis, Sherri Z.
Publicado no Oncotarget (2019)

Circulating Tumor DNA Identifies EGFR Co-Amplification as a Mechanism of Resistance to Crizotinib in a Patient with Advanced MET-Amplified Lung Adenocarcinoma

Por Dagogo-Jack, Ibiayi, Fabrizio, David, Lennerz, Jochen, Schrock, Alexa B., Young, Lauren, Mino-Kenudson, Man, Digumarthy, Subba R., Heist, Rebecca S., Ali, Siraj M., Miller, Vincent A., Shaw, Alice T.
Publicado no J Thorac Oncol (2017)

Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors

Por Goodman, Aaron M., Piccioni, David, Kato, Shumei, Boichard, Amélie, Wang, Huan-You, Frampton, Garrett, Lippman, Scott M., Connelly, Caitlin, Fabrizio, David, Miller, Vincent, Sicklick, Jason K., Kurzrock, Razelle
Publicado no JAMA Oncol (2018)

Prevalence of High Tumor Mutational Burden and Association With Survival in Patients With Less Common Solid Tumors

Por Shao, Changxia, Li, Gerald, Huang, Lingkang, Pruitt, Scott, Castellanos, Emily, Frampton, Garrett, Carson, Kenneth R., Snow, Tamara, Singal, Gaurav, Fabrizio, David, Alexander, Brian M., Jin, Fan, Zhou, Wei
Publicado no JAMA Netw Open (2020)

DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties

Por Samad, Tarek A., Srinivasan, Ashok, Karchewski, Laurie A., Jeong, Sung-Jin, Campagna, Jason A., Ji, Ru-Rong, Fabrizio, David A., Zhang, Ying, Lin, Herbert Y., Bell, Esther, Woolf, Clifford J.
Publicado no J Neurosci (2004)

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers

Por Riviere, Paul, Goodman, Aaron M, Okamura, Ryosuke, Barkauskas, Donald A., Whitchurch, Theresa J, Lee, Suzanna, Khalid, Noor, Collier, Rachel, Mareboina, Manvita, Frampton, Garrett M., Fabrizio, David, Sharabi, Andrew B., Kato, Shumei, Kurzrock, Razelle
Publicado no Mol Cancer Ther (2020)

BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy

Por Johnson, Douglas B., Childress, Merrida A., Chalmers, Zachary R., Frampton, Garrett M., Ali, Siraj M., Rubinstein, Samuel M., Fabrizio, David, Ross, Jeffrey S., Balasubramanian, Sohail, Miller, Vincent A., Stephens, Philip J., Sosman, Jeffrey A., Lovly, Christine M.
Publicado no Pigment Cell Melanoma Res (2017)

Comprehensive Genomic Profiling of Hodgkin Lymphoma Reveals Recurrently Mutated Genes and Increased Mutation Burden

Por Liang, Winnie S., Vergilio, Jo‐Anne, Salhia, Bodour, Huang, Helen J., Oki, Yasuhiro, Garrido‐Laguna, Ignacio, Park, Haeseong, Westin, Jason R., Meric‐Bernstam, Funda, Fabrizio, David, Miller, Vincent A., Stephens, Philip J., Fanale, Michelle A., Ross, Jeffrey S., Janku, Filip
Publicado no Oncologist (2018)

Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3

Por Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.
Publicado no Cancer (2018)

IMMU-13. LARGE SCALE TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE PREDISPOSITION AND REVEALS NOVEL CANDIDATES FOR IMMUNE CHECKPOINT...

Por Campbell, Brittany B., Angelini, Paola, Fabrizio, David, Elvin, Julia, Light, Nicholas, Bouffet, Eric, Larouche, Valerie, Samuel, David, Stearns, Duncan, Cole, Kristina, Opocher, Enrico, Thomas, Gregory, Sabel, Magnus, George, Ben, Ziegler, David, Lapierre, Norman, Mason, Gary, Magimajrajan, Vanan, Shlien, Adam, Tabori, Uri
Publicado no Neuro Oncol (2017)

Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition

Por Fabrizio, David A., George, Thomas J., Dunne, Richard F., Frampton, Garrett, Sun, James, Gowen, Kyle, Kennedy, Mark, Greenbowe, Joel, Schrock, Alexa B., Hezel, Aram F., Ross, Jeffrey S., Stephens, Phillip J., Ali, Siraj M., Miller, Vincent A., Fakih, Marwan, Klempner, Samuel J.
Publicado no J Gastrointest Oncol (2018)

HGG-17. TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE REPLICATION REPAIR DEFICIENCY AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBIT...

Por Campbell, Brittany B, Light, Nicholas, Fabrizio, David, Bouffet, Eric, Larouche, Valerie, Samuel, David, Stearns, Duncan, Cole, Kristina A, Opocher, Enrico, Thomas, Gregory, Sabel, Magnus, Dirks, Peter, Taylor, Michael, Malkin, David, Albrecht, Steffen, Dudley, Roy, Jabado, Nada, Hawkins, Cynthia, Shlien, Adam, Tabori, Uri
Publicado no Neuro Oncol (2018)

A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient S...

Por Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.
Publicado no J Mol Diagn (2019)