EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION

Hypermutant pediatric high grade gliomas (pHGG) constitute 5–10% of PHGG and are almost invariantly caused by replication repair deficiency (RRD). Constitutive activation of the RAS/MAPK pathway via oncogenic mutations can be targeted with MEK inhibitors (MEKi). We hypothesized that hypermutant RRD...

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Publicado no:Neuro Oncol
Main Authors: Campbell, Brittany B, Morgenstern, Daniel A, Lipman, Tatiana, Fabrizio, David, Shlien, Adam, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012157/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.175
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