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EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION
Hypermutant pediatric high grade gliomas (pHGG) constitute 5–10% of PHGG and are almost invariantly caused by replication repair deficiency (RRD). Constitutive activation of the RAS/MAPK pathway via oncogenic mutations can be targeted with MEK inhibitors (MEKi). We hypothesized that hypermutant RRD...
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| Vydáno v: | Neuro Oncol |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012157/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.175 |
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