Development of ATP-competitive mTOR Inhibitors

The mTOR mediated signaling transduction pathway has been observed to be deregulated in a wide variety of cancer and metabolic diseases. Despite extensive clinical development efforts, the well-known allosteric mTOR inhibitor rapamycin and structurally related rapalogs have failed to show significan...

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Huvudupphovsmän: Liu, Qingsong, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Wang, Jinhua, Chang, Jae Won, Markhard, Andrew, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964610/
https://ncbi.nlm.nih.gov/pubmed/22125084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-430-8_29
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