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Development of ATP-competitive mTOR Inhibitors
The mTOR mediated signaling transduction pathway has been observed to be deregulated in a wide variety of cancer and metabolic diseases. Despite extensive clinical development efforts, the well-known allosteric mTOR inhibitor rapamycin and structurally related rapalogs have failed to show significan...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964610/ https://ncbi.nlm.nih.gov/pubmed/22125084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-430-8_29 |
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