The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling

The mTOR protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined the mTOR-regulated phosphoproteome by quantitative mass spectrometry and characterized the primary sequence moti...

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Bibliographic Details
Main Authors: Hsu, Peggy P., Kang, Seong A., Rameseder, Jonathan, Zhang, Yi, Ottina, Kathleen A., Lim, Daniel, Peterson, Timothy R., Choi, Yongmun, Gray, Nathanael S., Yaffe, Michael B., Marto, Jarrod A., Sabatini, David M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177140/
https://ncbi.nlm.nih.gov/pubmed/21659604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1199498
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