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The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are found in a somatic mosaic fashion in patients with multiple enchondromas. Enchondromas are benign cartilaginous tumors arising in the medulla of bone. The mutant IDH1/2 causes elevated levels of D-2-hydroxyglutarate (D-2-HG). Mesenchymal st...
Tallennettuna:
Julkaisussa: | Oncotarget |
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Päätekijät: | , , , , |
Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
Impact Journals LLC
2015
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4558118/ https://ncbi.nlm.nih.gov/pubmed/26046462 |
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