The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are found in a somatic mosaic fashion in patients with multiple enchondromas. Enchondromas are benign cartilaginous tumors arising in the medulla of bone. The mutant IDH1/2 causes elevated levels of D-2-hydroxyglutarate (D-2-HG). Mesenchymal st...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Suijker, Johnny, Baelde, Hans J., Roelofs, Helene, Cleton-Jansen, Anne-Marie, Bovée, Judith V.M.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558118/
https://ncbi.nlm.nih.gov/pubmed/26046462
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