Cancer-Associated Isocitrate Dehydrogenase Mutations

Por Yen, Katharine E., Schenkein, David P.
Publicado em 2012

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

Por Clark, Owen, Yen, Katharine, Mellinghoff, Ingo K.
Publicado no Clin Cancer Res (2016)

Hepsin Cooperates with Myc in the Progression of Adenocarcinoma in a Prostate Cancer Mouse Model

Por Nandana, Srinivas, Ellwood-Yen, Katharine, Sawyers, Charles, Wills, Marcia, Weidow, Brandy, Case, Thomas, Vasioukhin, Valeri, Matusik, Robert
Publicado em 2010

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors

Por Clegg, Nicola J., Couto, Suzana S., Wongvipat, John, Hieronymus, Haley, Carver, Brett S., Taylor, Barry S., Ellwood-Yen, Katharine, Gerald, William L., Sander, Chris, Sawyers, Charles L.
Publicado em 2011

Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance

Por Kats, Lev M., Reschke, Markus, Taulli, Riccardo, Pozdnyakova, Olga, Burgess, Kerri, Bhargava, Parul, Straley, Kimberly, Karnik, Rahul, Meissner, Alexander, Small, Donald, Su, Shinsan M., Yen, Katharine, Zhang, Jiangwen, Pandolfi, Pier Paolo
Publicado no Cell Stem Cell (2014)

The NF-κB Pathway Controls Progression of Prostate Cancer to Androgen Independent Growth

Por Jin, Ren Jie, Lho, Yongsoo, Connelly, Linda, Wang, Yongqing, Yu, Xiuping, Jean, Leshana Saint, Case, Thomas C., Ellwood-Yen, Katharine, Sawyers, Charles L., Bhowmick, Neil A., Blackwell, Timothy S., Yull, Fiona E., Matusik, Robert J.
Publicado em 2008

Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate

Por Fathi, Amir T., Sadrzadeh, Hossein, Comander, Amy H., Higgins, Michaela J., Bardia, Aditya, Perry, Ashley, Burke, Meghan, Silver, Regina, Matulis, Christina R., Straley, Kimberly S., Yen, Katharine E., Agresta, Sam, Kim, Hyeryun, Schenkein, David P., Borger, Darrell R.
Publicado em 2014

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Por Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei, Yen, Katharine E.
Publicado no Blood (2015)

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma

Por Tap, William D., Villalobos, Victor M., Cote, Gregory M., Burris, Howard, Janku, Filip, Mir, Olivier, Beeram, Murali, Wagner, Andrew J., Jiang, Liewen, Wu, Bin, Choe, Sung, Yen, Katharine, Gliser, Camelia, Fan, Bin, Agresta, Sam, Pandya, Shuchi S., Trent, Jonathan C.
Publicado no J Clin Oncol (2020)

Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia

Por Shih, Alan H, Meydan, Cem, Shank, Kaitlyn, Garrett-Bakelman, Francine E, Ward, Patrick S, Intlekofer, Andrew, Nazir, Abbas, Stein, Eytan, Knapp, Kristina, Glass, Jacob, Travins, Jeremy, Straley, Kim, Gliser, Camelia, Mason, Chris, Yen, Katharine, Thompson, Craig B, Melnick, Ari, Levine, Ross L
Publicado no Cancer Discov (2017)

ACTR-31. PHASE 1 STUDY OF AG-881, AN INHIBITOR OF MUTANT IDH1 AND IDH2: RESULTS FROM THE RECURRENT/PROGRESSIVE GLIOMA POPULATION

Por Mellinghoff, Ingo, Penas-Prado, Marta, Peters, Katherine, Cloughesy, Timothy, Burris, Howard, Maher, Elizabeth, Janku, Filip, Cote, Gregory, De La Fuente, Macarena, Clarke, Jennifer, Steelman, Lori, Le, Kha, Xu, Huansheng, Sonderfan, Alison, Hummel, Diana, Schoenfeld, Steven, Yen, Katharine, Pandya, Shuchi, Wen, Patrick
Publicado no Neuro Oncol (2018)

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

Por Amatangelo, Michael D., Quek, Lynn, Shih, Alan, Stein, Eytan M., Roshal, Mikhail, David, Muriel D., Marteyn, Benoit, Farnoud, Noushin Rahnamay, de Botton, Stephane, Bernard, Olivier A., Wu, Bin, Yen, Katharine E., Tallman, Martin S., Papaemmanuil, Elli, Penard-Lacronique, Virginie, Thakurta, Anjan, Vyas, Paresh, Levine, Ross L.
Publicado no Blood (2017)

RBTT-03. A PHASE 1, MULTICENTER, RANDOMIZED, OPEN-LABEL, PERIOPERATIVE STUDY OF AG-120 (IVOSIDENIB) AND AG-881 IN PATIENTS WITH RECURRENT, NONENHANCING, IDH1-MUTANT, LOW-GRADE GLIO...

Por Mellinghoff, Ingo, Maher, Elizabeth, Wen, Patrick, Cloughesy, Timothy, Peters, Katherine, Choi, Changho, Ellingson, Benjamin, Lin, Alexander, Li, Yan, Soher, Brian, Young, Robert, Steelman, Lori, Le, Kha, Yin, Feng, Wu, Bin, Lu, Min, Zhang, Yanwei, Nicolay, Brandon, Schoenfeld, Steven, Yen, Katharine, Pandya, Shuchi, Clarke, Jennifer
Publicado no Neuro Oncol (2018)

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

Por Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy M., Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E., Yang, Hua, Straley, Kimberly S., Jin, Shengfang, Kunii, Kaiko, Fantin, Valeria R., Zhang, Shunan, Pan, Qiongqun, Shi, Derek, Biller, Scott A., Su, Shinsan M.
Publicado em 2012

A prostatic intraepithelial neoplasia-dependent p27(kip1) checkpoint induces senescence, inhibits cell proliferation and cancer progression

Por Majumder, Pradip K., Grisanzio, Chiara, O’Connell, Fionnuala, Barry, Marc, Brito, Joseph M., Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L., Signoretti, Sabina, Hahn, William C., Loda, Massimo, Sellers, William R.
Publicado em 2008

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

Por Sasaki, Masato, Knobbe, Christiane B., Itsumi, Momoe, Elia, Andrew J., Harris, Isaac S., Chio, Iok In Christine, Cairns, Rob A., McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E., Su, Shinsan M., Mak, Tak Wah
Publicado em 2012

Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC(2)) Low-grade Glioma Research Workshop

Por Huse, Jason T., Wallace, Max, Aldape, Kenneth D., Berger, Mitchel S., Bettegowda, Chetan, Brat, Daniel J., Cahill, Daniel P., Cloughesy, Timothy, Haas-Kogan, Daphne A., Marra, Marco, Miller, C. Ryan, Nelson, Sarah J., Salama, Sofie R., Soffietti, Riccardo, Wen, Patrick Y., Yip, Stephen, Yen, Katharine, Costello, Joseph F., Chang, Susan
Publicado em 2014

ACTR-46. AG-120, A FIRST-IN-class MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: UPDATED RESULTS FROM THE PHASE 1 NON-ENHANCING GLIOMA POPULATI...

Por Mellinghoff, Ingo K, Touat, Mehdi, Maher, Elizabeth, De La Fuente, Macarena, Cloughesy, Timothy F, Holdhoff, Matthias, Cote, Gregory M, Burris, Howard, Janku, Filip, Huang, Ray, Young, Robert J, Ellingson, Benjamin, Nimkar, Tara, Jiang, Liewen, Ishii, Yuko, Choe, Sung, Fan, Bin, Steelman, Lori, Yen, Katharine, Bowden, Chris, Pandya, Susan, Wen, Patrick Y
Publicado no Neuro Oncol (2017)

Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma

Por Mellinghoff, Ingo K., Ellingson, Benjamin M., Touat, Mehdi, Maher, Elizabeth, De La Fuente, Macarena I., Holdhoff, Matthias, Cote, Gregory M., Burris, Howard, Janku, Filip, Young, Robert J., Huang, Raymond, Jiang, Liewen, Choe, Sung, Fan, Bin, Yen, Katharine, Lu, Min, Bowden, Chris, Steelman, Lori, Pandya, Shuchi S., Cloughesy, Timothy F., Wen, Patrick Y.
Publicado no J Clin Oncol (2020)

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

Por DiNardo, Courtney D., Propert, Kathleen J., Loren, Alison W., Paietta, Elisabeth, Sun, Zhuoxin, Levine, Ross L., Straley, Kimberly S., Yen, Katharine, Patel, Jay P., Agresta, Samuel, Abdel-Wahab, Omar, Perl, Alexander E., Litzow, Mark R., Rowe, Jacob M., Lazarus, Hillard M., Fernandez, Hugo F., Margolis, David J., Tallman, Martin S., Luger, Selina M., Carroll, Martin
Publicado em 2013