Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid leukemia (AML) patients correlate with IDH mutations, and whether diagnostic or r...

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Main Authors: DiNardo, Courtney D., Propert, Kathleen J., Loren, Alison W., Paietta, Elisabeth, Sun, Zhuoxin, Levine, Ross L., Straley, Kimberly S., Yen, Katharine, Patel, Jay P., Agresta, Samuel, Abdel-Wahab, Omar, Perl, Alexander E., Litzow, Mark R., Rowe, Jacob M., Lazarus, Hillard M., Fernandez, Hugo F., Margolis, David J., Tallman, Martin S., Luger, Selina M., Carroll, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682342/
https://ncbi.nlm.nih.gov/pubmed/23641016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-493197
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