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Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced nicotinamide adenine dinucleotide phosphate (NADPH) from NADP(+). Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human...
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| Veröffentlicht in: | Clin Cancer Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4834266/ https://ncbi.nlm.nih.gov/pubmed/26819452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1333 |
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