Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance

Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in human acute myeloid leukemia (AML). 2-HG modulates numerous biological pathways implicated in malignant transformation, but the contribution o...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Kats, Lev M., Reschke, Markus, Taulli, Riccardo, Pozdnyakova, Olga, Burgess, Kerri, Bhargava, Parul, Straley, Kimberly, Karnik, Rahul, Meissner, Alexander, Small, Donald, Su, Shinsan M., Yen, Katharine, Zhang, Jiangwen, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380188/
https://ncbi.nlm.nih.gov/pubmed/24440599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.12.016
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