Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance

অনুযায়ী Kats, Lev M., Reschke, Markus, Taulli, Riccardo, Pozdnyakova, Olga, Burgess, Kerri, Bhargava, Parul, Straley, Kimberly, Karnik, Rahul, Meissner, Alexander, Small, Donald, Su, Shinsan M., Yen, Katharine, Zhang, Jiangwen, Pandolfi, Pier Paolo
প্রকাশিত Cell Stem Cell (2014)

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

অনুযায়ী Gross, Stefan, Cairns, Rob A., Minden, Mark D., Driggers, Edward M., Bittinger, Mark A., Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P., Su, Shinsan M., Dang, Lenny, Fantin, Valeria R., Mak, Tak W.
প্রকাশিত 2010

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

অনুযায়ী Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei, Yen, Katharine E.
প্রকাশিত Blood (2015)

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzymatic activity that converts α-ketoglutarate to 2-hydroxyglutarate

অনুযায়ী Ward, Patrick S., Patel, Jay, Wise, David R., Abdel-Wahab, Omar, Bennett, Bryson D., Coller, Hilary A., Cross, Justin R., Fantin, Valeria R., Hedvat, Cyrus V., Perl, Alexander E., Rabinowitz, Joshua D., Carroll, Martin, Su, Shinsan M., Sharp, Kim A., Levine, Ross L., Thompson, Craig B.
প্রকাশিত 2010

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

অনুযায়ী Jin, Shengfang, Chen, Jiang, Chen, Lizao, Histen, Gavin, Lin, Zhizhong, Gross, Stefan, Hixon, Jeffrey, Chen, Yue, Kung, Charles, Chen, Yiwei, Fu, Yufei, Lu, Yuxuan, Lin, Hui, Cai, Xiujun, Yang, Hua, Cairns, Rob A., Dorsch, Marion, Su, Shinsan M., Biller, Scott, Mak, Tak W., Cang, Yong
প্রকাশিত Proc Natl Acad Sci U S A (2015)

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

অনুযায়ী Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy M., Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E., Yang, Hua, Straley, Kimberly S., Jin, Shengfang, Kunii, Kaiko, Fantin, Valeria R., Zhang, Shunan, Pan, Qiongqun, Shi, Derek, Biller, Scott A., Su, Shinsan M.
প্রকাশিত 2012

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

অনুযায়ী Sasaki, Masato, Knobbe, Christiane B., Itsumi, Momoe, Elia, Andrew J., Harris, Isaac S., Chio, Iok In Christine, Cairns, Rob A., McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E., Su, Shinsan M., Mak, Tak Wah
প্রকাশিত 2012

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

অনুযায়ী Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari, Zúñiga-Pflücker, Juan-Carlos, Mak, Tak W.
প্রকাশিত 2012

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

অনুযায়ী Dang, Lenny, White, David W., Gross, Stefan, Bennett, Bryson D., Bittinger, Mark A., Driggers, Edward M., Fantin, Valeria R., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Prins, Robert M., Ward, Patrick S., Yen, Katharine E., Liau, Linda M., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Vander Heiden, Matthew G., Su, Shinsan M.
প্রকাশিত 2009

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

অনুযায়ী Pope, Whitney B., Prins, Robert M., Thomas, M. Albert, Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.
প্রকাশিত 2011

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

অনুযায়ী Dang, Lenny, White, David W., Gross, Stefan, Bennett, Bryson D., Bittinger, Mark A., Driggers, Edward M., Fantin, Valeria R., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Prins, Robert M., Ward, Patrick S., Yen, Katharine E., Liau, Linda M., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Vander Heiden, Matthew G., Su, Shinsan M.
প্রকাশিত 2010

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

অনুযায়ী Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.
প্রকাশিত 2013

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

অনুযায়ী Kung, Charles, Hixon, Jeff, Choe, Sung, Marks, Kevin, Gross, Stefan, Murphy, Erin, DeLaBarre, Byron, Cianchetta, Giovanni, Sethumadhavan, Shalini, Wang, Xiling, Yan, Shunqi, Gao, Yi, Fang, Cheng, Wei, Wentao, Jiang, Fan, Wang, Shaohui, Qian, Kevin, Saunders, Jeff, Driggers, Ed, Woo, Hin Koon, Kunii, Kaiko, Murray, Stuart, Yang, Hua, Yen, Katharine, Liu, Wei, Cantley, Lewis C., Vander Heiden, Matthew G., Su, Shinsan M., Jin, Shengfang, Salituro, Francesco G., Dang, Lenny
প্রকাশিত 2012