Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site resulting in loss of the enzyme’s ability to catalyze conversion of isocitrate to α-...

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Autors principals: Dang, Lenny, White, David W., Gross, Stefan, Bennett, Bryson D., Bittinger, Mark A., Driggers, Edward M., Fantin, Valeria R., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Prins, Robert M., Ward, Patrick S., Yen, Katharine E., Liau, Linda M., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Vander Heiden, Matthew G., Su, Shinsan M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818760/
https://ncbi.nlm.nih.gov/pubmed/19935646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08617
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