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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site resulting in loss of the enzyme’s ability to catalyze conversion of isocitrate to α-...
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
2009
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818760/ https://ncbi.nlm.nih.gov/pubmed/19935646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08617 |
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