Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell fate decision. We demonstrate that LRF is key for instructing ear...

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Main Authors: Maeda, Takahiro, Merghoub, Taha, Hobbs, Robin M., Dong, Lin, Maeda, Manami, Zakrzewski, Johannes, van den Brink, Marcel R. M., Zelent, Arthur, Shigematsu, Hirokazu, Akashi, Koichi, Teruya-Feldstein, Julie, Cattoretti, Giorgio, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978506/
https://ncbi.nlm.nih.gov/pubmed/17495164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1140881
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