Immunotherapy and the belly of the beast

Por Merghoub, Taha, Wolchok, Jedd D.
Publicado no J Exp Med (2014)

The importance of animal models in tumor immunity and immunotherapy

Por Budhu, Sadna, Wolchok, Jedd, Merghoub, Taha
Publicado no Curr Opin Genet Dev (2013)

Direct comparisons of T cell costimulation and checkpoint blockade in the setting of tumor-targeted monoclonal antibody therapy

Por Khalil, Danny, Merghoub, Taha, Wolchok, Jedd
Publicado no J Immunother Cancer (2015)

Myeloid-derived suppressor cells and the efficacy of CD8(+) T-cell immunotherapy

Por Lesokhin, Alexander M., Merghoub, Taha, Wolchok, Jedd D.
Publicado em 2013

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressi...

Por Holmgaard, Rikke B., Zamarin, Dmitriy, Lesokhin, Alexander, Merghoub, Taha, Wolchok, Jedd D.
Publicado no EBioMedicine (2016)

Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis

Por Piazza, Francesco, Costoya, José A., Merghoub, Taha, Hobbs, Robin M., Pandolfi, Pier Paolo
Publicado em 2004

Expression of indoleamine 2.3-dioxygenase by tumors induces local and systemic immunosuppressive effects in a murine melanoma model

Por Holmgaard, Rikke B, Zamarin, Dmitriy, Munn, David H, Merghoub, Taha, Wolchok, Jedd D
Publicado no J Immunother Cancer (2014)

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment

Por Budhu, Sadna, Schaer, David, Li, Yongbiao, Houghton, Alan, Silverstein, Samuel, Merghoub, Taha, Wolchok, Jedd
Publicado em 2013

Potentiation of immunomodulatory antibodies with oncolytic viruses for therapy of poorly-immunogenic tumors

Por Zamarin, Dmitriy, Holmgaard, Rikke B, Plitt, Tamar, Allison, James, Merghoub, Taha, Wolchok, Jedd D
Publicado no J Immunother Cancer (2014)

Impairment of Treg suppression by GITR ligation is effective selectively in the context of a pro-inflammatory tumor microenvironment

Por Zappasodi, Roberta, Budhu, Sadna, Schaer, David, Yang, Xia, Zhong, Hong, Merghoub, Taha, Wolchok, Jedd D
Publicado no J Immunother Cancer (2014)

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment

Por Budhu, Sadna, Schaer, David, Li, Yongbiao, Houghton, Alan, Silverstein, Samuel, Merghoub, Taha, Wolchok, Jedd D
Publicado no J Immunother Cancer (2014)

Genetics and immunology: reinvigorated

Por Snyder, Alexandra, Makarov, Vladimir, Hellmann, Matthew, Rizvi, Naiyer, Merghoub, Taha, Wolchok, Jedd D, Chan, Timothy A
Publicado no Oncoimmunology (2015)

Localized oncolytic virotherapy inflames distant tumors and synergizes with immune checkpoint blockade leading to systemic tumor rejection

Por Zamarin, Dmitriy, Holmgaard, Rikke, Subudhi, Sumit, Mansour, Mena, Palese, Peter, Merghoub, Taha, Wolchok, Jedd D, Allison, James P
Publicado em 2013

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice

Por Murphy, Judith T., Burey, Andre P., Beebe, Amy M., Gu, Danling, Presta, Leonard G., Merghoub, Taha, Wolchok, Jedd D.
Publicado em 2014

DEVELOPMENT OF EFFECTIVE VACCINES FOR OLD MICE IN A TUMOR MODEL

Por Posnett, David N, Engelhorn, Manuel E., Lin, Yun, Merghoub, Taha, Duan, Fei, Wolchok, Jedd D, Houghton, Alan N
Publicado no Vaccine (2008)

Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1

Por Liao, Ching, Wang, Xiang Yuan, Wei, Hong Quan, Li, Sherry Q., Merghoub, Taha, Pandolfi, Pier Paolo, Wolgemuth, Debra J.
Publicado em 2001

Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3

Por Deng, Liang, Dai, Peihong, Parikh, Tanvi, Cao, Hua, Bhoj, Vijay, Sun, Qinmiao, Chen, Zhijian, Merghoub, Taha, Houghton, Alan, Shuman, Stewart
Publicado em 2008

Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner

Por Holmgaard, Rikke B., Zamarin, Dmitriy, Li, Yanyun, Gasmi, Billel, Munn, David H., Allison, James P., Merghoub, Taha, Wolchok, Jedd D.
Publicado no Cell Rep (2015)

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

Por Zamarin, Dmitriy, Holmgaard, Rikke B., Ricca, Jacob, Plitt, Tamar, Palese, Peter, Sharma, Padmanee, Merghoub, Taha, Wolchok, Jedd D., Allison, James P.
Publicado no Nat Commun (2017)

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

Por Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F., Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N., Wolchok, Jedd D.
Publicado em 2010