Aprenda em 14 dias MCSE windows NT server 4 /

par Schaer, David.
Publié 1998.

Modulation of GITR for cancer immunotherapy

par Schaer, David A, Murphy, Judith T, Wolchok, Jedd D
Publié 2012

Hiding the road signs that lead to tumor immunity

par Schaer, David A., Lesokhin, Alexander M., Wolchok, Jedd D.
Publié 2011

Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

par Schaer, David A, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd D
Publié 2014

Modulation of CTLA-4 and GITR for Cancer Immunotherapy

par Avogadri, Francesca, Yuan, Jianda, Yang, Arvin, Schaer, David, Wolchok, Jedd D.
Publié 2011

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment

par Budhu, Sadna, Schaer, David, Li, Yongbiao, Houghton, Alan, Silverstein, Samuel, Merghoub, Taha, Wolchok, Jedd
Publié 2013

Impairment of Treg suppression by GITR ligation is effective selectively in the context of a pro-inflammatory tumor microenvironment

par Zappasodi, Roberta, Budhu, Sadna, Schaer, David, Yang, Xia, Zhong, Hong, Merghoub, Taha, Wolchok, Jedd D
Publié dans J Immunother Cancer (2014)

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment

par Budhu, Sadna, Schaer, David, Li, Yongbiao, Houghton, Alan, Silverstein, Samuel, Merghoub, Taha, Wolchok, Jedd D
Publié dans J Immunother Cancer (2014)

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy

par Holmgaard, Rikke B., Brachfeld, Alexandra, Gasmi, Billel, Jones, David R., Mattar, Marissa, Doman, Thompson, Murphy, Mary, Schaer, David, Wolchok, Jedd D., Merghoub, Taha
Publié dans Oncoimmunology (2016)

GITR Pathway Activation Abrogates Tumor Immune Suppression Through Loss of Regulatory T cell Lineage Stability

par Schaer, David A., Budhu, Sadna, Liu, Cailian, Bryson, Campbell, Malandro, Nicole, Cohen, Adam, Zhong, Hong, Yang, Xia, Houghton, Alan N., Merghoub, Taha, Wolchok, Jedd D.
Publié 2013

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

par Budhu, Sadna, Schaer, David A., Li, Yongbiao, Toledo-Crow, Ricardo, Panageas, Katherine, Yang, Xia, Zhong, Hong, Houghton, Alan N., Silverstein, Samuel C., Merghoub, Taha, Wolchok, Jedd D.
Publié dans Sci Signal (2017)

Detection of Intra-Tumor Self Antigen Recognition during Melanoma Tumor Progression in Mice Using Advanced Multimode Confocal/Two Photon Microscope

par Schaer, David A., Li, Yongbiao, Merghoub, Taha, Rizzuto, Gabrielle A., Shemesh, Amos, Cohen, Adam D., Li, Yanyun, Avogadri, Francesca, Toledo-Crow, Ricardo, Houghton, Alan N., Wolchok, Jedd D.
Publié 2011

Targeting the TGFβ pathway with galunisertib, a TGFβRI SMI, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint i...

par Schaer, David, Li, Yanxia, Castaneda, Stephen, Inigo, Ivan, Surguladze, David, Xu, Xiaohong, Nugent, Desiree, Murphy, Mary, Hall, Gerald, Benhadji, Karim, Guba, Susan, Li, Yiwen, Kalos, Michael, Driscoll, Kyla
Publié dans J Immunother Cancer (2015)

FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety

par Alakhras, Nada S., Qiu, Jiabin, Rocha, Guilherme V., Witcher, Derrick R., Koester, Anja, You, Jinsam, Schaer, David A., Holmgaard, Rikke B., Driscoll, Kyla, Willy, Jeffrey A., Malherbe, Laurent P.
Publié dans MAbs (2018)

Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma

par Benezra, Miriam, Penate-Medina, Oula, Zanzonico, Pat B., Schaer, David, Ow, Hooisweng, Burns, Andrew, DeStanchina, Elisa, Longo, Valerie, Herz, Erik, Iyer, Srikant, Wolchok, Jedd, Larson, Steven M., Wiesner, Ulrich, Bradbury, Michelle S.
Publié 2011

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

par Cohen, Adam D., Schaer, David A., Liu, Cailian, Li, Yanyun, Hirschhorn-Cymmerman, Daniel, Kim, Soo Chong, Diab, Adi, Rizzuto, Gabrielle, Duan, Fei, Perales, Miguel A., Merghoub, Taha, Houghton, Alan N., Wolchok, Jedd D.
Publié 2010

Rational design of anti-GITR-based combination immunotherapy

par Zappasodi, Roberta, Sirard, Cynthia, Li, Yanyun, Budhu, Sadna, Abu-Akeel, Moshen, Liu, Cailian, Yang, Xia, Zhong, Hong, Newman, Walter, Qi, Jingjing, Wong, Philip, Schaer, David, Koon, Henry, Velcheti, Vamsidhar, Postow, Michael A., Callahan, Margaret K., Wolchok, Jedd D., Merghoub, Taha
Publié dans Nat Med (2019)

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combinat...

par Holmgaard, Rikke B., Schaer, David A., Li, Yanxia, Castaneda, Stephen P., Murphy, Mary Y., Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R., Iversen, Philip W., Surguladze, David, Hall, Gerald E., Novosiadly, Ruslan D., Benhadji, Karim A., Plowman, Gregory D., Kalos, Michael, Driscoll, Kyla E.
Publié dans J Immunother Cancer (2018)

Peripheral blood and tumor biomarkers in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab

par Callahan, Margaret K, Horak, Christine E, Curran, Michael A, Hollman, Travis, Schaer, David A, Yuan, Jianda, Lesokhin, Alexander M, Kitano, Shigehisa, Hong, Quan, Ariyan, Charlotte E, Busam, Klaus J, Feely, William, Jure-Kunkel, Maria, Grosso, Joseph, Simon, Jason S, Korman, Alan J, Wigginton, Jon M, Gupta, Ashok K, Zhang, Xiaoling, Phillips, Therese, Simmons, Pauline, Sznol, Mario, Wolchok, Jedd D
Publié 2013

Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody

par Gombos, Randi B., Gonzalez, Ana, Manrique, Mariana, Chand, Dhan, Savitsky, David, Morin, Benjamin, Breous-Nystrom, Ekaterina, Dupont, Christopher, Ward, Rebecca A., Mundt, Cornelia, Duckless, Benjamin, Tang, Hao, Findeis, Mark A., Schuster, Andrea, Waight, Jeremy D., Underwood, Dennis, Clarke, Christopher, Ritter, Gerd, Merghoub, Taha, Schaer, David, Wolchok, Jedd D., van Dijk, Marc, Buell, Jennifer S., Cuillerot, Jean-Marie, Stein, Robert, Drouin, Elise E., Wilson, Nicholas S.
Publié dans PLoS One (2018)