Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

Regulatory T cells (T(regs)) suppress antitumor immunity by inhibiting the killing of tumor cells by antigen-specific CD8(+) T cells. To better understand the mechanisms involved, we used ex vivo three-dimensional (3D) collagen-fibrin gel cultures of dissociated B16 melanoma tumors. This system reca...

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Publicado en:Sci Signal
Autores principales: Budhu, Sadna, Schaer, David A., Li, Yongbiao, Toledo-Crow, Ricardo, Panageas, Katherine, Yang, Xia, Zhong, Hong, Houghton, Alan N., Silverstein, Samuel C., Merghoub, Taha, Wolchok, Jedd D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851440/
https://ncbi.nlm.nih.gov/pubmed/28851824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aak9702
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