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Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
Regulatory T cells (T(regs)) suppress antitumor immunity by inhibiting the killing of tumor cells by antigen-specific CD8(+) T cells. To better understand the mechanisms involved, we used ex vivo three-dimensional (3D) collagen-fibrin gel cultures of dissociated B16 melanoma tumors. This system reca...
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| 發表在: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851440/ https://ncbi.nlm.nih.gov/pubmed/28851824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aak9702 |
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