Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy

Colony stimulating factor-1 (CSF-1) is produced by a variety of cancers and recruits myeloid cells that suppress antitumor immunity, including myeloid-derived suppressor cells (MDSCs.) Here, we show that both CSF-1 and its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, an...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncoimmunology
Päätekijät: Holmgaard, Rikke B., Brachfeld, Alexandra, Gasmi, Billel, Jones, David R., Mattar, Marissa, Doman, Thompson, Murphy, Mary, Schaer, David, Wolchok, Jedd D., Merghoub, Taha
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2016
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006914/
https://ncbi.nlm.nih.gov/pubmed/27622016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1151595
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