Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

The cytotoxic T lymphocyte antigen-4 (CTLA-4)–blocking antibody ipilimumab results in durable responses in metastatic melanoma, though therapeutic benefit has been limited to a fraction of patients. This calls for identification of resistance mechanisms and development of combinatorial strategies. H...

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Hauptverfasser: Holmgaard, Rikke B., Zamarin, Dmitriy, Munn, David H., Wolchok, Jedd D., Allison, James P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698523/
https://ncbi.nlm.nih.gov/pubmed/23752227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130066
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