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Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

The cytotoxic T lymphocyte antigen-4 (CTLA-4)–blocking antibody ipilimumab results in durable responses in metastatic melanoma, though therapeutic benefit has been limited to a fraction of patients. This calls for identification of resistance mechanisms and development of combinatorial strategies. H...

詳細記述

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書誌詳細
主要な著者: Holmgaard, Rikke B., Zamarin, Dmitriy, Munn, David H., Wolchok, Jedd D., Allison, James P.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698523/
https://ncbi.nlm.nih.gov/pubmed/23752227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130066
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